Anthelmintic activity of unripe Mangifera indica L. (Mango) against Strongyloides stercoralis

Strongyloidiasis is a parasitic disease, caused by a nematode helminth, Strongyloides stercoralis. The true prevalence of S. stercoralis is likely underestimated because infection is often subclinical. Currently, an estimated 100 million people are infected worldwide in more than 70 countries (Concha et al., 2005 -. Segarra et al., 2007). Though many advances have been made in the diagnosis and treatment of strongyloidiasis, it still prevails as one of the elusive diseases to tackle in the present day world. It is an intestinal nematode, endemic in tropical and subtropical regions. The humidity and clay soils favor the development of larvae stages of the parasite in the environment. The filariform larvae (L3) are the infective stage. Upon skin penetration, they travel to the bloodstream and reach the lung. After ascending the tracheobronchial tree, they arrive in the small intestine, where they evolve to adult stages and females begin the oviposition in the intestinal wall. Rhabditoid larvae emerge from these eggs; they may differentiate into L3 in the environment or to auto infected filariform stage (aL3) in the host intestine, the latter being able to penetrate through the bowel ISSN: 2319-7706 Volume 2 Number 5 (2013) pp. 401-409 http://www.ijcmas.com